# Expectations and possible side effects > Future Formula When can I expect to see results with the Future Formula? Everyone’s skin is unique and therefore, everyone experiences resul... Source: https://support.agencyskin.com/en_us/expectations-and-possible-side-effects-HkjJNhu3_ Last updated: 2026-08-25T05:41:05.975Z ## **Night Renew****Rx** **Important info about tretinoin**Some of our Night RenewRx formulas contain tretinoin. Here is some important information regarding tretinoin —Do not wax - it's possible that the top layer of skin could be removed with the wax. This can leave hyperpigmentation that may take months to fade. Try tweezing or threading instead. —People who are pregnant, breastfeeding, or trying to get pregnant should not use tretinoin. If any of these apply to you, please let your provider know so they can change your formula. **Important info about estriol** Some of our Night RenewR formulas contain estriol, a topical estrogen prescribed for eligible patients. Here is some important information regarding estriol: —People who are pregnant, breastfeeding, or trying to get pregnant should not use estriol. If any of these apply to you, please let your medical provider know so they can change your formula. ### —Estriol isn't right for everyone. Your provider will screen for certain medical conditions before prescribing an estriol-containing formula. **When can I expect to see results with Night Renew****Rx** **?**  Everyone’s skin is unique and therefore, everyone experiences results on different timelines. Your results depend on a few things, like the ingredients in your Night RenewRx, its prescription strength, and if you are wearing sun protection regularly (which you should!). You may see results after a few weeks or after many months of regular use (along with sun protection). That said, continued use of your Night RenewRx will also help work against further skin damage and help “slow” the skin aging process. In other words, people will still develop signs of aging while using Night RenewRx, but they are expected to be milder and not occur as quickly as they would have without treatment. ### **What are the possible risks and side effects associated with Night Renew****Rx****?** For formulas with tretinoin, sun sensitivity may occur. Tretinoin can be degraded by UV light, and it can increase the skin's sensitivity to the sun. It is important to apply the formula at night and to apply sunscreen daily. Tretinoin may also cause flaking, peeling, and irritation, especially if you have dry or sensitive skin. Skin can also become more sensitive when tretinoin is used. Burning, stinging, or itching may occur initially as your skin adjusts to your formula. If your formula contains estriol, you may notice redness, itching, or burning at the application site, or darkening of the skin similar to melasma. * * * ## **Dark Spot****Rx** **Important info about hydroquinone**Some of our Dark SpotRx formulas contain hydroquinone. Here are some tips for how to use hydroquinone appropriately: —Wear sunscreen every day - SPF 30 and up. Dark spots can worsen with sun exposure even with treatment, so it's important to apply sunscreen consistently. —Apply formula directly to dark spots and patches. Use your fingertips for bigger areas, or a cotton swab if applying to just a few small dark spots. Follow your medical provider’s instructions for use. —Avoid applying on eyelids and near mucous membranes (i.e., eyes, inside of nostrils, and mouth). —People who are pregnant, breastfeeding, or trying to get pregnant should not use hydroquinone. If any of these apply to you, please let your provider know. ### **When can I expect to see results with the Dark Spot****Rx****?**  It’s important to have realistic expectations when using the Dark SpotRx! It usually takes 8-12 weeks of consistent treatment and strict sun protection to notice any lightening of dark spots. Keep in mind, this timeline varies from person to person. If you don’t see any improvement in hyperpigmentation after several months of treatment, you can message your provider to talk about the possibility of trying new active ingredients in your personalized formula. If your dark spots are particularly stubborn, your provider may recommend consulting a local dermatologist to talk about alternative options.   ### **What are the possible risks and side effects associated with the Dark Spot****Rx****?**   Just like any other prescription medication, Dark SpotRx comes with possible risks, but you can help minimize them by following your provider’s instructions. Possible side effects include irritation, itching, rashes, or allergic reactions where the formula is applied. It’s possible to unintentionally lighten the skin surrounding your dark spots when treating them with hydroquinone, creating a “halo spot.” It’s usually possible for the skin to return to normal but may take several months.   When used long-term, there is a small risk that hydroquinone can lead to permanent blue/black darkening of the skin, so it’s important to follow your provider’s instructions and take breaks from your Dark SpotRx as directed. Also, note that using a hydroquinone topical together with peroxide products (including but not limited to benzoyl peroxide and hydrogen peroxide) may stain your skin. This staining can usually be removed with soap and water. If you notice halo spots forming, dark spots getting darker, or other discoloration, please stop using the formula and let your Agency provider know.  It’s possible—although very rare—to see more serious side effects with long-term topical corticosteroid use, especially at higher strengths. These side effects include HPA axis suppression, Cushing syndrome, hyperglycemia, cataracts, glaucoma, and intracranial hypertension. As always, if you notice any unusual symptoms while using Dark SpotRx, please stop using it and reach out to your provider for guidance. As a result of these possible side effects, we do require anyone requesting an additional shipment of Dark SpotRx, to reach out to their provider first for approval. * * * ## **Eye Revive****Rx** ### **Important info about tretinoin** Some of our Eye ReviveRx formulas contain tretinoin. Here is some important information regarding tretinoin:  —Apply as directed, and avoid your eyelids, lash line, and the inside corners of your eyes. If the formula gets into your eyes, rinse thoroughly with cool water.  —People who are pregnant, breastfeeding, or trying to get pregnant should not use tretinoin. If any of these apply to you, please let your provider know so they can change your formula. ### **When can I expect to see results with Eye Revive****Rx****?** Everyone's skin is unique, so results vary from person to person. Your results depend on a few things, like the ingredients in your Eye ReviveRx, its prescription strength, and how consistently you use it (along with daily sun protection!). Eye ReviveRx is formulated specifically for the delicate skin around the eyes, and with regular use, some people notice smoother fine lines and crow's feet, a brighter and more even under-eye area, and skin that feels more hydrated. You may begin to see results after a few weeks or after several months of regular use — for best results, be patient and consistent. ### **What are the possible risks and side effects associated with Eye Revive****Rx****?** Just like any other prescription medication, Eye ReviveRx comes with possible risks, but you can help minimize them by following your provider's instructions. Because the skin around the eyes is thinner and more sensitive than the rest of the face, this area can be more prone to irritation. Possible side effects include burning, stinging, itching, dryness, redness, and peeling, especially as your skin first adjusts to your formula. For formulas with tretinoin, sun sensitivity may also occur, so it's important to apply your formula at night and wear sunscreen daily. If you have a history of dry or sensitive eyes, or notice ongoing irritation of your eyelids or eyes, stop using the formula and reach out to your Agency provider. * * * ## **Day Defender****Rx** ### **Important info about vitamin C** Day DefenderRx is powered by a customized level of vitamin C (L-ascorbic acid), along with resveratrol, green tea extract, and niacinamide. Here are some tips for getting the most out of your formula:  —Apply in the morning, then follow with moisturizer and sunscreen (SPF 30 or higher) — Day DefenderRx is designed to work alongside sun protection, not replace it.  —Start slow, especially at higher vitamin C strengths. Your provider may recommend applying to a small area first before using it on your full face.  —A gradual yellow tint is normal. Vitamin C naturally oxidizes over time when exposed to air, light, and water — this doesn't mean your formula has lost its effectiveness. ### **When can I expect to see results with Day Defender****Rx****?** Everyone's skin is unique, so results vary from person to person. Your results depend on a few things, like your vitamin C strength and how consistently you use sun protection alongside your formula. With regular use, some people notice brighter, more even-looking skin over several weeks to months. Because Day DefenderRx is designed to help defend against daily environmental damage, continued use may also help support your skin's resilience over time. ### **What are the possible risks and side effects associated with Day Defender****Rx****?** Just like any other prescription medication, Day DefenderRx comes with possible risks, but you can help minimize them by following your provider's instructions. Possible side effects include tingling, burning or stinging, redness, dryness, and irritation, especially when you first start treatment or after an increase in vitamin C strength. This is usually temporary. If irritation doesn't improve, message your provider; they may recommend using your formula less often or adjusting your vitamin C strength. * * * ## **Cell Repair****Rx** ### **Important info about rapamycin** Cell RepairRx contains rapamycin (also called sirolimus). Here is some important information regarding rapamycin:  —Certain medications and supplements can interact with rapamycin. Let your provider know about everything you're taking, and check in again if you start something new. —Avoid use around facial procedures — stop using Cell RepairRx at least 2 weeks before any facial procedure (like a chemical peel, laser treatment, or microneedling), and check with your provider before starting again.  —People who are pregnant, breastfeeding, or trying to get pregnant should not use rapamycin. If any of these apply to you, please let your provider know so they can change your formula.  —For external use only. Avoid your eyes and mouth, and don't cover, wrap, or bandage the treated area. ### **When can I expect to see results with the Cell Repair****Rx****?** Everyone's skin is unique, so results vary from person to person. Many people use it alongside Night RenewRx as part of a nighttime routine, and your provider will let you know how to layer the two if you're using both.  ### **What are the possible risks and side effects associated with the Cell Repair****Rx****?** Just like any other prescription medication, the Cell RepairRx comes with possible risks, but you can help minimize them by following your provider's instructions. Possible side effects include dryness, irritation where the formula is applied, itching, and increased sensitivity to the sun, so daily sunscreen is a must. Your provider will also recommend an annual skin check while you're using Cell RepairRx.