# Agency Day Defender Rx Important Safety Information > Please read this first Agency Day Defender Rx is a compounded prescription medication Agency Day Defender Rx is a compounded prescription medication It is Source: https://support.agencyskin.com/en_us/agency-day-defender-rx-important-safety-information-Bknn9zUPMg Last updated: 2026-08-22T14:24:35.501Z **Please read this first: Agency Day Defender Rx is a compounded prescription medication** **Agency Day Defender Rx is a compounded prescription medication.** It is prepared for you by a state-licensed compounding pharmacy operating under Section 503A of Federal Food, Drug & Cosmetic Act (“Section 503A”), pursuant to a prescription drug order issued by your prescribing licensed medical provider for a determined clinical need. **Compounded prescription medications are not FDA-approved.** The FDA has not evaluated Agency Day Defender Rx for safety or efficacy through its drug approval process. Agency Day Defender Rx’s combination of ingredients each individually comply with Section 503A, but the combination compounded medication has not been evaluated or approved by the FDA for safety and efficacy. Agency makes no claims of safety and efficacy with respect to Agency Day Defender Rx. **There is no single, fixed formula.** The active pharmaceutical ingredients (APIs) and strengths in Agency Day Defender Rx are determined by a prescribing licensed medical provider after an appropriate medical evaluation and patient consultation based on skin needs, skincare goals, medical history, and medical exam. Prescription formulas may be different from one patient to another, and they may change over time.  **What Agency Day Defender Rx is for** Agency Day Defender Rx is a personalized morning treatment powered by customizable vitamin C strengths and complementary antioxidants, aiming to help target oxidative stress while protecting against UV exposure, pollution, and environmental damage associated with visible skin aging. Agency Day Defender Rx intends to potentially support brighter-, more even-looking skin while helping calm inflammation and maintain skin resilience. _Results may vary. Product and ingredients are subject to medical evaluation and patient consultation where the medical provider evaluating you determines the compounded prescription medication is appropriate for use._ **Agency Day Defender Rx is designed to be used with sunscreen. It is not a sunscreen and does not replace one.** **Before you start** Consult with dermatology medical provider about any medical conditions and all medications you are taking before using this compounded prescription medication. Agency Day Defender Rx will be assigned a beyond use date in accordance with Section 503A and United States Pharmacopeia (USP) standards. Do not use this medication after the date listed on the prescription label. **Who should not use Agency Day Defender Rx** If you are currently pregnant or breastfeeding, do not use the Agency Day Defender Rx. Do not use this medication if you are allergic to any of its active or base ingredients, including vitamin C (L-ascorbic acid), resveratrol, green tea extract (epigallocatechin gallate), or niacinamide. Resveratrol is structurally similar to estrogens and has been classified a phytoestrogen. If you have any condition that can worsen with exposure to estrogen, talk with your medical provider before using this medication. **Active pharmaceutical ingredients (APIs) that may be in your Agency Day Defender Rx formula compounded prescription medication** The APIs in your Agency Day Defender Rx are selected and prescribed by your state-licensed prescribing medical provider. Prescription drug products and APIs are subject to medical consultation. The APIs used within your compounded prescription medication will be listed on your Day Defender Rx bottle label in accordance with state and federal law. Consult your medical provider if you have questions about the APIs included within your compounded prescription medications. Please inform your medical provider of all allergies, including allergies to ingredients that may be in the Agency Day Defender Rx. These may include: * Vitamin C (L-ascorbic acid) — your strength is personalized by your medical provider * Resveratrol * Green tea extract (epigallocatechin gallate) * Niacinamide **Base inactive ingredients in Agency Day Defender Rx** The base ingredients for each Day Defender Rx compounded prescription medication include: Aqua Purificata, Cetearyl Alcohol, Polysorbate 60, Isohexadecane, Isododecane, C13-C15 Alkane, Glyceryl Stearate, PEG-75 Stearate, Polyacrylate-13, Polyisobutene, Polysorbate 20, Polyurethane-39, Stearyl Behenate, Cetyl Alcohol, Tocopheryl Acetate, Ascorbic Acid, Sodium Bisulfite, Benzoic Acid, Sorbic Acid, and Propanediol. **Please review the base ingredients if you have allergies, as we do not screen for allergies to the product base.** **Warnings** Skin irritation may occur as a side effect of this medication. This can include tingling, burning or stinging, redness, dryness, itching, and temporary irritation. Irritation is more likely at higher vitamin C strengths and when you first start treatment. Please contact your medical provider if this occurs. Start slowly, especially at higher vitamin C strengths. Your prescribing medical provider may direct you to apply the medication to the back of your hand first, then to a small area of your face for a few days, before using it on your full face. If significant irritation occurs, reduce how often you apply the compounded prescription medication or stop use and contact your medical provider. Avoid applying to broken, cut, or very irritated skin. To reduce the risk of skin irritation, avoid other products that may irritate the skin. This includes the use of abrasive soaps, exfoliants, and related chemicals or obtaining facial treatments including but not limited to waxing and electrolysis. A broad-spectrum sunscreen product with at least SPF 30 should be used daily. Apply the Day Defender Rx compounded prescription medication in the morning, follow with moisturizer if needed, and finish with sunscreen as the final step in your morning routine. **A note on color:** vitamin C naturally oxidizes when exposed to air, light, and water. Over time your compounded prescription medication may develop a slight yellow tint, which may be most visible at the opening of the bottle. This is expected, and the compounded prescription medication remains potent through the beyond use date printed on your prescription bottle. **Common side effects** Dry skin or peeling may occur. Some ingredients cannot be used if pregnant or breastfeeding. Do not use the Agency Day Defender Rx compounded prescription medication if you are allergic to any ingredients or if an allergic reaction occurs. Tingling, burning or stinging, redness, itching, and irritation may occur, most often when you first start using this compounded prescription medication or after an increase in vitamin C strength. These reactions are usually temporary but contact your medical provider if this occurs.  Stop use and contact your healthcare provider right away if you develop symptoms of an allergic reaction such as rash, hives, itching, shortness of breath, wheezing, cough, or swelling of your face, lips, tongue, or throat. **Please tell your medical provider if** * You are pregnant, nursing, or trying to get pregnant. * You have had any allergic reactions to skin care products. * If you have been diagnosed with rosacea. * If you have a history of eczema, perioral dermatitis, skin cancer, or other skin conditions. * You are using any other prescription or over-the-counter topical treatments, including retinoids or exfoliating acids. * You are taking any other medications that make you more sensitive to sunlight. **How to use** This compounded prescription medication treatment was designed to be applied once daily in the morning. Apply a thin layer to clean, dry skin on your face and neck, then follow with moisturizer and sunscreen. Do not use more than your prescribing medical provider has instructed you to use. Do not swallow and avoid sensitive areas such as eyes, lips, mucous membranes, and inside your mouth/nose. Do not use on cuts, scrapes, damaged (broken/chapped/cut/irritated/scraped) skin, recently shaved areas of the skin, or sunburned skin. Doing any of these things may increase the chance of undesirable side effects. If using Day Defender Rx in your morning routine, apply Skin Smoothing Booster in the evening. Please always follow your prescribing medical provider’s specific directions on how to use your Agency Day Defender Rx compounded prescription medication. **Important summary** This page does not list every possible risk, side effect, warning, or interaction associated with Agency Day Defender Rx, and it is not a substitute for a full consultation and patient counseling with your prescribing medical provider. Your prescribing medical provider knows your medical history and prescribed the compounded prescription medication specifically to meet your clinical needs. Talk with your prescribing medical provider before you start, stop, or change how you use this compounded prescription medication, and tell them about all of your medical conditions and allergies, and all medications and supplements you take, including over-the-counter products. **Reporting a side effect** If you experience a side effect, contact your Agency prescribing medical practitioner through your account. If you think you are having a medical emergency, call 911 or go to the nearest emergency room. **Who compounds this medication:** Agency Day Defender Rx is compounded and dispensed by Personalized Skin Solutions, Inc., a state-licensed compounding pharmacy operating in compliance with Section 503A  located at 155 Solar Drive, Imperial, PA 15126 (1-888-210-4777). Agency does not manufacture or compound this medication. Questions about how your prescription was compounded, or about your specific ingredient list, can be directed to your medical provider through your account or the pharmacy at the number above.